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新长春硷—Vindesine 的药物动力学与神经毒性,介于长春新硷和花硷之间,对急淋白血病、某些淋巴瘤、乳腺癌与非小细胞性肺癌有疗效。作者对13例烷化剂有抗药性的晚期多发性骨髓瘤。患者(ⅢA 及ⅢB 期)进行了 Vindesine 治疗。开始剂量3mg/m~2,每周静注1针,用3周停3周。有3例因神经毒性和白细胞减少减为2mg/m~2。并口服强的松100mg/日×5。如副作用严重,应待
Pharmacokinetics and neurotoxicity of neo vinblastin-Vindesine, between vincristine and theophylline, are efficacious in acute leukemia, certain lymphomas, breast and non-small cell lung cancers. The author of 13 cases of alkylating agents resistant multiple myeloma. Patients (stage IIIA and stage IIIB) were treated with Vindesine. Start dose 3mg / m ~ 2, 1 intravenous injection a week, with 3 weeks to stop 3 weeks. There were 3 cases of neurotoxicity and leukopenia reduced to 2mg / m ~ 2. And oral prednisone 100mg / day × 5. Serious side effects, should be