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目的观察短期胰岛素强化治疗对初诊断2型糖尿病患者胰岛α细胞及β细胞功能的影响。方法选取初诊2型糖尿病患者28例,给予餐时胰岛素加基础胰岛素强化治疗(三餐前速效人胰岛素类似物+甘精胰岛素)10 d,治疗前后均行标准馒头餐试验,治疗前后均检测空腹、餐后30 min及餐后120 min的静脉血糖、C-肽及胰高血糖素。结果与强化治疗前相比,治疗后患者各时点静脉血糖明显下降,C-肽曲线下面积增加,胰高血糖素曲线面积下降,各时点C-肽/胰高血糖素比升高(P<0.05)。强化治疗后HOMA-IR指数降低(P<0.05)。结论胰岛素短期强化治疗可改善初诊2型糖尿病患者的β细胞及α细胞功能。
Objective To observe the effects of short-term insulin intensive therapy on islet α-cell and β-cell function in newly diagnosed type 2 diabetic patients. Methods 28 patients with newly diagnosed type 2 diabetes mellitus were enrolled in this study. Meal insulin plus basal insulin (pre-fasting insulin analogue plus insulin glargine) was given for 10 days. The standard steamed bread meal test was performed before and after treatment. , Postprandial 30 min and postprandial 120 min venous glucose, C-peptide and glucagon. Results Compared with that before intensive treatment, the patients’ venous blood glucose decreased obviously, the area under the curve of C-peptide increased, the area of glucagon curve decreased, and the C-peptide / glucagon ratio at each time point increased P <0.05). HOMA-IR index decreased after intensive treatment (P <0.05). Conclusion Short-term intensive insulin therapy can improve β-cell and α-cell function in newly diagnosed type 2 diabetic patients.