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目的:分析中西医结合对先兆流产早期患者的疗效及妊娠结局的影响。方法:112例先兆流产早期患者,按数字单盲法将患者分为对照组(56例)和观察组(56例)。对照组患者采用西药治疗的方案,患者给予20mg/d的黄体酮肌肉注射,同时加服维生素E、叶酸。观察组在对照组治疗的基础上联合口服中药进行治疗。对患者进行定期回访或定期检查,详细记录两组患者治疗前后的激素含量、治疗的有效率、患者妊娠期及分娩期的不良反应、观察新生儿的不良结局等。结果:治疗前,两组患者血清中β-HGC、E2、P的含量无明显差异,对比无统计学意义(P>0.05);患者治疗后,血清中β-HGC、E2、P的含量有明显提高,但观察组患者的变化明显优于对照组,差异有统计学意义(P<0.05)。两组患者经过治疗后,观察组的总有效率91.07%明显高于对照组的总有效率75.00%(P<0.05)。两组患者在妊娠期及分娩期的并发症主要有妊娠期糖尿病、高血压,胎膜早破,产后流血等;观察组患者的并发症发生率10.71%与对照组并发症发生率12.50%无明显差异(P>0.05)。但观察组的保胎成功率92.86%明显高于对照组的保胎成功率83.93%(P<0.05);观察组的新生儿畸形、低Apgars评分、足月低体重儿的人数与对照组无明显差异,差异具无统计学意义(P>0.05)。结论:采用中西医结合的方案治疗先兆流产早期患者,能明显改善患者的激素水平,提高患者治疗的成功率,不增加妊娠期及分娩期的不良并发症,不增加新生儿不良结局的发生,值得临床采纳推广。
Objective: To analyze the effect of integrated traditional Chinese and western medicine on early curative effect of threatened abortion and pregnancy outcome. Methods: One hundred and twelve patients with early threatened abortion were divided into control group (56 cases) and observation group (56 cases) according to the single-blind method. Control group of patients treated with Western medicine program, patients given 20mg / d progesterone intramuscular injection, while taking vitamin E, folic acid. Observation group in the control group based on the treatment of oral Chinese medicine for treatment. Regular visits to patients or regular inspection, detailed records of two groups of patients before and after treatment of hormone content, the effectiveness of treatment, patients with adverse reactions during pregnancy and childbirth, observation of adverse neonatal outcomes. Results: There was no significant difference in serum β-HGC, E2 and P levels between the two groups before treatment (P> 0.05). After treatment, the content of β-HGC, E2 and P (P <0.05). However, the changes in the observation group were significantly better than those in the control group (P <0.05). After treatment, the total effective rate in the observation group was 91.07%, which was significantly higher than that in the control group (75.00%, P <0.05). Complications in both groups during pregnancy and childbirth were mainly gestational diabetes mellitus, hypertension, premature rupture of membranes and postpartum bleeding. The complication rate in observation group was 10.71% and that in control group was 12.50% Significant difference (P> 0.05). However, the success rate of miscarriage in observation group was significantly higher than that in control group (92.86% vs 83.93%, P <0.05). Neonatal malformation, low Apgars score, number of full-term and low- Significant differences, the difference was not statistically significant (P> 0.05). Conclusion: The combination of traditional Chinese and Western medicine treatment of threatened abortion early patients, can significantly improve the patient’s hormone levels and improve the success rate of treatment of patients without increasing complications during pregnancy and childbirth, does not increase the incidence of neonatal adverse outcomes, It is worth clinical promotion.