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特异的组胺H_2受体拮抗剂—甲氰咪胍,可以增强机体健乳素的释放,但是这一作用既不能被H_2受体阻断剂所增强,也不能被H_2受体激动剂所减弱。最近的研究表明甲氰咪胍可以抑制苯二氮(艹卓)类或GABA与大脑中的受体结合,提示甲氰咪胍对于GABA能神经系统的作用可能是其诱导催乳素释放的机制之一。 雄性Sprague—Dowleg鼠250—300克,颈静脉插管72小时后加入甲氰咪胍(或盐水作对照),第一组在注入甲氰咪胍10分钟前,注入甲双咪胍(Impromidine)1mg/kg,第二组在注入甲氰咪胍前5分钟注入安定3mg/kg或氯羟安定(L-orazepam)3mg/kg或GABA 5mg/kg,第一组在注射甲氰咪胍前3分钟同时注入安定1.5mg/
Specific histamine H 2 receptor antagonist - cimetidine, can enhance the release of body-building hormone, but this effect can neither be enhanced by H 2 receptor blockers, nor can H 2 receptor agonist decreased . Recent studies have shown that cimetidine inhibits the binding of benzodiazepines or GABA to receptors in the brain suggesting that the effect of cimetidine on GABAergic system may be the mechanism by which it induces prolactin release one. 250-300 g of male Sprague-Dowleg mice, cidimetidine (or saline as control) 72 hours after cannulation of the jugular vein, and the first group was injected with Impromidine 10 minutes before the injection of cimetidine, 1 mg / kg in the second group, 3 mg / kg diazepam or 3 mg / kg L-orazepam or 5 mg / kg GABA in the second group before the injection of cimetidine five minutes before the injection of cimetidine Min while injecting diazepam 1.5mg /