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目的 探讨脑干损伤早期延脑网状结构的超微病理变化。方法 将实验大鼠分为创伤组和对照组，透射电镜观察大鼠机械性脑干损伤早期（１０ｍｉｎ，０ ．５ｈ，１ｈ ，３ｈ） 延脑网状结构的超微病理变化。结果 脑干损伤１０ｍｉｎ 即可见神经微丝（ｎｅｕｒｏｆｉｌａｍｅｎｔ， ＮＦ） 排列紊乱、疏密不均，ＮＦ 臂的缺失，髓鞘层面分离，轴膜内皱，与髓鞘间形成空隙，微血管周围基质密度降低以及线粒体肿胀等超微病变。脑干伤后存活时间延长，上述病变更为显著。本文就上述超微病变的形成机制及病理学意义进行了探讨。结论 脑干机械性损伤能够明显引起延脑网状结构的超微病理学变化，并增加个体快速死亡和免疫组化染色的易感性
Objective To investigate the ultrastructural changes of the network structure of the brain in early brain stem injury. Methods The experimental rats were divided into the trauma group and the control group. The ultrastructural changes of the medulla oblongata network in the early stage of mechanical brain injury (10 min, 0.5 h, 1 h, 3 h) were observed by transmission electron microscopy. Results The brainstem injury 10min showed neurofilament (NF) disordered arrangement, uneven density, lack of NF arm, separation of myelin layer, axial membrane wrinkles, and the formation of gaps between the myelin sheath, microvascular density decreased around the matrix As well as mitochondrial swelling and other superficial lesions. Survival time after brain stem injury, the above lesions is more significant. In this paper, the formation mechanism of ultra-small lesions and pathological significance were discussed. Conclusion The mechanical damage of the brainstem can obviously cause the ultrastructural changes of the network structure of the brain and increase the susceptibility of the individual to rapid death and immunohistochemical staining