论文部分内容阅读
目的探讨RbAp48在子宫内膜腺癌中的表达及临床意义。方法收集标本,采用免疫组织化学SP法检测72例正常子宫内膜组织(增生期21例,分泌期27例,绝经期24例)、27例子宫内膜不典型增生、52例不同分化程度的子宫内膜腺癌组织标本中RbAp48蛋白的表达,并分析RbAp48表达与临床病理特征的关系。结果子宫内膜腺癌组织中RbAp48的表达高于正常子宫内膜及子宫内膜不典型增生,与增生期无关(P>0.05),与分泌期、绝经期及不典型增生有关(P<0.05);分化程度低的腺癌RbAp48表达比分化程度高的腺癌RbAp48表达高,RbAp48表达与FIGO分期、远处转移、孕激素服用史、肌层浸润深度以及肥胖、糖尿病等有关,与年龄、月经初潮、痛经、体质量指数、盆腔淋巴结转移、淋巴血管间隙受累无关。结论 RbAp48在正常子宫内膜、子宫内膜不典型增生及子宫内膜腺癌组织中均有表达,腺癌组织中RbAp48表达上调,提示其可能在子宫内膜腺癌中发挥重要作用。
Objective To investigate the expression of RbAp48 in endometrial adenocarcinoma and its clinical significance. Methods The specimens were collected and 72 cases of normal endometrium (21 cases of proliferative stage, 27 cases of secretory stage and 24 cases of menopausal stage) were detected by immunohistochemical SP method, 27 cases of endometrial dysplasia and 52 cases of different degree of differentiation The expression of RbAp48 protein in endometrial adenocarcinoma was analyzed. The relationship between RbAp48 expression and clinicopathological features was also analyzed. Results The expression of RbAp48 in endometrial adenocarcinoma was higher than that in normal endometrium and endometrial atypical hyperplasia (P <0.05), which was associated with secretory phase, menopause and dysplasia (P <0.05) ). The expression of RbAp48 in adenocarcinoma with low degree of differentiation was higher than that in adenocarcinoma with high degree of differentiation. RbAp48 expression correlated with FIGO stage, distant metastasis, taking progesterone, depth of myometrial invasion, obesity and diabetes, Menarche, dysmenorrhea, body mass index, pelvic lymph node metastasis, lymphatic vascular space involvement has nothing to do. Conclusions RbAp48 is expressed in normal endometrium, endometrial dysplasia and endometrial adenocarcinoma. The up-regulation of RbAp48 in adenocarcinoma suggests that RbAp48 may play an important role in endometrial adenocarcinoma.