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目的探讨高频振荡通气(HFOV)治疗新生儿呼吸窘迫综合征(RDS)的临床效果。方法选择2012年2月~2013年7月本院收治、需机械通气的RDS患儿70例,随机分为HFOV组和常频机械通气(CMV)组,比较两组患儿肺功能、并发症、机械通气时间及住院时间。结果机械通气1 h后,两组患儿吸入氧浓度(FiO2)、氧合指数(OI)、平均气道压(MAP)、动脉血二氧化碳分压(PaCO2)均较0 h有不同程度改善,且在1 h及6 h HFOV组较CMV组改善更明显,差异有统计学意义(P<0.05);机械通气24 h后HFOV组的OI、MAP仍较CMV组低,差异有统计学意义(P<0.05)。HFOV组患儿机械通气时间、住院时间短于CMV组(P<0.05);两组气漏、支气管肺发育不良、早产儿视网膜病变等并发症发生率差异无统计学意义(P>0.05)。结论 HFOV能更好更快的改善RDS患儿的肺氧合功能,缩短病程,同时并不增加并发症的发生率。
Objective To investigate the clinical effect of high frequency oscillatory ventilation (HFOV) on neonatal respiratory distress syndrome (RDS). Methods Seventy patients with RDS who underwent mechanical ventilation in our hospital from February 2012 to July 2013 were randomly divided into HFOV group and regular frequency mechanical ventilation group (CMV). The pulmonary function, complications , Mechanical ventilation time and hospitalization time. Results After 1 h of mechanical ventilation, FiO2, OI, MAP and PaCO2 in two groups were all improved to some extent compared with 0 h, (P <0.05). After 24 h of mechanical ventilation, the OI and MAP in HFOV group were still lower than those in CMV group (P <0.05), the difference was statistically significant (P < P <0.05). The duration of mechanical ventilation and hospital stay in HFOV group were shorter than those in CMV group (P <0.05). There were no significant differences in the incidence of complications such as air leak, bronchopulmonary dysplasia and retinopathy of prematurity between the two groups (P> 0.05). Conclusions HFOV can improve the oxygenation function and shorten the course of the disease in children with RDS better and faster, and does not increase the incidence of complications.