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观察了17-β羟雌二醇（17-β-estradiol，E2）及其代谢产物2-羟雌酮（2-hydroxyestrone，2－OHE1）、2-羟雌二醇（2－hydroxyestradiol，2－OHE2）和多巴胺（dopamine，DA）受体激动剂piribedil对大鼠垂体前叶细胞（aneriorpituitarycells，APC）增殖的影响。结果表明：E2（10－6mol/L）可促进APC生长，A10－5mol/L的piribedil却可抑制APC的增殖活性。提前12h加入E2或2－OHE2、2－OHE2可抑制piribedil的效应，但E2对piribedil效应无明显影响。
The effects of 17-β-estradiol (E2) and its metabolites 2-hydroxyestrone (2-OHE1) and 2-hydroxyestradiol OHE2) and dopamine (DA) receptor agonist piribedil on the proliferation of rat anterior pituitary cells (APCs). The results showed that: E2 (10-6mol / L) can promote the growth of APC, A10-5mol / L of piribedil can inhibit APC proliferation activity. Addition of E2 or 2-OHE2,2-OHE2 12 h prior to injection inhibited piribedil’s effect, but E2 had no significant effect on piribedil.