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机体在电离辐射作用下发生蛋白质合成抑制同时分解代谢增强。同化激素像特异的酶活化剂一样对蛋白合成起刺激作用。并减慢蛋白质加速分解。同化剂也具有辐射防护作用。文献中曾报导过关于照后使用大力补可减轻动物蛋白总含量下降及组织蛋白酶升高的程度,也报告过皋丸酮有辐射防护作用。曾有人证明同化激素大力补能明显提高胱胺预防效果。为此,作者于1974年研究了同化激素以及其它类似制剂在动物实验中和辐射防护剂的协同作用。实验用雄性小鼠。厢射630和800伦,X线剂量率为44.4伦/分;或~(60)Coγ线照射750伦。照射前3天开始给小鼠(每组15只)腹腔注射苯丙酸诺龙10mg/公斤,葵酸诺龙和睾酮苯丙酸酯25mg/公斤。给对照组腹腔注射0.5ml油溶剂。另外1组动物于照后应用激素。辐射防护剂通常在照前20分钟注射,因2-巯基丙酰甘氨
The body under the action of ionizing radiation protein synthesis inhibition while enhancing catabolism. Assimilation hormones like specific enzyme activators stimulate protein synthesis. And slow down protein accelerated decomposition. Anabolic agents also have radioprotective effects. It has been reported in the literature that the use of clarithromycin after irradiation may reduce the total amount of animal protein and increase the degree of cathepsin, and also report that radiolynol has a radioprotective effect. It has been demonstrated that strong assimilation hormone can significantly improve the cystamine preventive effect. To this end, the authors studied the synergistic effect of anabolic hormones and other similar formulations in animal experiments with radioprotectants in 1974. Experimental male mice. Valens 630 and 800 Lun, X-ray dose rate of 44.4 Lun / min; or ~ (60) Co γ ray irradiation 750 Lun. Three days before irradiation, mice (15 in each group) were intraperitoneally injected with 10 mg / kg nandrolone phenylpropionate, nandrolone and testosterone phenylpropionate 25 mg / kg. Control group intraperitoneal injection of 0.5ml oil solvent. Another group of animals in the application of hormones after irradiation. Radioprotective agents are usually injected 20 minutes prior to injection due to 2-mercaptopropionylglycine