流行性感冒(流感)嗜血杆菌(Haemophilus Influenzae,Hi)分为有荚膜的可分型(a～f型)和无荚膜的不可分型菌株,有荚膜的b型Hi(Hi Type b,Hib)是引起侵袭性感染,包括脑膜炎、肺炎的主要病原体,但Hib的感染有疫苗可以预防。不可分型Hi是导致儿童感染的重要病原体之一,可引起多种疾病,包括肺炎、中耳炎等,目前无疫苗预防。现将国内外对不可分型Hi的致病因子和致病机理进行综述,为疫苗的研制、疾病的治疗和预防控制提供帮助。 Influenza (influenza) Haemophilus Influenzae (Hi) is divided into capsule typeable (a ~ f type) and non-capsule type inseparable strains, capsule type Hi Hi , Hib) is a major causative agent of invasive infections, including meningitis and pneumonia, but vaccines against Hib can be prevented. Inseparable Hi is one of the important pathogens that cause children’s infection and can cause many diseases, including pneumonia and otitis media. At present, there is no vaccine prevention. At present, the etiological factor and pathogenic mechanism of undivided Hi are summarized at home and abroad, which helps to develop vaccines, treat diseases and prevent and control them.