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目的探讨在根治性切除原发性肿瘤的前提条件下,联合应用肝移植治疗肝转移癌是否为一种合理性的策略。方法借鉴国外的相关经验,实施结、直肠癌Dixon术联合原位肝移植2例次,胃癌D4根治术联合原位肝移植1例次。结果3例患者中,有2例分别于术后4个月和8个月死于肿瘤复发;1例结、直肠癌患者无瘤存活16个月余。结论对部分具有较好生物学特性的消化道肿瘤伴肝转移,原发性肿瘤切除联合肝移植可作为少数患者获得治疗机会的一种选择。
Objective To explore whether the combined application of liver transplantation for liver metastases is a reasonable strategy under the premise of radical excision of primary tumors. Methods Based on the experience of other countries, Dixon’s surgery combined with orthotopic liver transplantation was performed in 2 cases. The radical resection of gastric cancer was performed in one case with D4 radical surgery and orthotopic liver transplantation. Results Of the 3 patients, 2 died of tumor recurrence at 4 months and 8 months respectively. One patient with colorectal cancer survived for more than 16 months without tumor. Conclusion Some patients with good biological characteristics of gastrointestinal cancer with liver metastases, primary tumor resection combined with liver transplantation as a minority of patients access to treatment options as an opportunity.