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用荧光分光光度法，测定１００例癫痫患者脑脊液（ＣＳＦ）中５－羟吲哚乙酸（５－ＨＩＡＡ）的含量。结果表明，癫痫组５－ＨＩＡＡ含量（３５．８９±２．９７ｎｇ／ｍｌ）明显低于对照组（５１．１７±３．８３ｎｇ／ｍｌ），Ｐ＜０．０１。症状控制后，５－ＨＩＡＡ含量显著回升（５２．５８±２．８９ｎｇ／ｍｌ）．癫痫发作越频繁，５－ＨＩＡＡ降低越显著（２７．４０±４．７２ｎｇ／ｍｌ）。癫痫发作３天内，５－ＨＭＡ含量降低最明显（２７．０３±３．５６ｎｇ／ｍｌ）。
Fluorescence spectrophotometry was used to determine the content of 5-HIAA in cerebrospinal fluid (CSF) of 100 patients with epilepsy. The results showed that the content of 5-HIAA in epilepsy group (35.89 ± 2.97ng / ml) was significantly lower than that in control group (51.17 ± 3.83ng / ml), P <0.01. After symptom control, the content of 5-HIAA increased significantly (52.58 ± 2.89ng / ml). The more frequent seizures, the more significant 5-HIAA reduction (27.40 ± 4.72 ng / ml). Within 3 days of seizure, the 5-HMA content decreased the most obviously (27.03 ± 3.56ng / ml).