【摘 要】
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Morphine and other opioids are among the most effective analgesics for treating pain.However, drug dependence and other deleterious side effects of opioids have
【机 构】
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International Collaborative Centre on Big Science Plan for Purine Signaling, Chengdu University of T
论文部分内容阅读
Morphine and other opioids are among the most effective analgesics for treating pain.However, drug dependence and other deleterious side effects of opioids have limited their clinical applicability.Recent studies suggest that the use of opioids for pain control may even exacerbate disease outcomes in some pain-producing conditions, such as acute pancreatitis [1].Thus, there is a clinically unmet demand for the discovery of new therapeutic targets for developing a new generation of analgesics potentially devoid of opioid-like adverse side effects.In most cases, the initial proof-of-concept identification of a protein as a potential druggable target is dependent on the use of genetically modified rodent models, such as gene-knockout mice.
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