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目的:比较不同抗结核药物与氧氟沙星及环丝氨酸对胸椎结核患者的临床疗效。方法:采用回顾性分析法分析2011年9月—2015年5月期间经抗结核药物治疗后施行手术的多节段胸椎结核患者37例,将其分为A组14例、B组17例和C组6例;术前分别给予A组“HREZ”抗结核治疗,B组HRE/Z与氧氟沙星治疗,C组HRE/Z与环丝氨酸治疗;药物治疗后再行手术治疗,比较各组患者手术前后药物治疗时间、住院时间和红细胞沉降率(ESR)、脊柱侧弯的角度(Cobb’s)及肌力等指标的变化情况。结果:3组患者手术后ESR均低于治疗前(P<0.05),A组和B组患者手术后Cobb’s均小于手术前(P<0.05)。结论:采用HREZ与氧氟沙星及环丝氨酸治疗胸椎结核患者疗效较为显著。
Objective: To compare the clinical effects of different anti-tuberculosis drugs and ofloxacin and cycloserine on patients with thoracic tuberculosis. Methods: A retrospective analysis was performed to analyze 37 patients with multi-segment thoracic tuberculosis treated by antitubercular drugs between September 2011 and May 2015. The patients were divided into group A (14 cases), group B (17 cases) and group B 6 cases in group C were treated with anti-TB therapy of group A and group HREZ and ofloxacin, group C was treated with HRE / Z and serine serine, The changes of drug treatment time, hospital stay and erythrocyte sedimentation rate (ESR), Cobb’s and muscle strength were compared before and after operation. Results: The ESR of the three groups after operation was lower than that before treatment (P <0.05). The Cobb’s of patients in group A and group B after operation were less than those before operation (P <0.05). Conclusion: The treatment of thoracic tuberculosis with HREZ, ofloxacin and cycloserine is more effective.