C_1抑制物(C_1 inhibitor,C_1 INH)活性测定对诊断C_1抑制物缺乏症有重要意义。本法比C_1 INH抗原量的测定更敏感,对遗传性C_1抑制物缺乏症(即遗传性血管性水肿)的变异型,本项检查是现有唯一具有诊断意义的指标。 C_1 INH活性的测定方法很多,诸如C_1酯酶活性抑制法,C_1溶血活性抑制法以及激肽释放酶抑制法。1984年Agostini在研究凝血因子。灭活动力学时发现,体内的前激肽释放酶激活剂(prekallikrein C_1 inhibitor (C_1INH) activity determination of C_1 inhibitor deficiency diagnosis of great significance. This method is more sensitive than the determination of the amount of C 1 INH antigen. This test is the only diagnostic criteria available for variants of hereditary C_1 inhibitor deficiency (ie hereditary angioedema). There are many ways to determine C INH activity, such as C 1 esterase activity inhibition, C 1 hemolytic activity inhibition and kallikrein inhibition. Agostini 1984 in the study of coagulation factors. Inactivation kinetics was found when the body’s prekallikrein activator (prekallikrein