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目的探讨 P-糖蛋白 ( Pgp)在胃癌组织中的表达并分析其与胃癌临床病理特点、术前化疗及预后的关系 .方法应用免疫组织化学法检测手术切除的 101例胃癌、 20例正常胃黏膜、 18例异型增生组织标本中 Pgp的表达 .结果正常胃黏膜、异型增生及未经术前化疗的胃癌中 Pgp表达依次增强 (P< 0 05)；经术前化疗后胃癌 Pgp表达增强 ,且与化疗次数相关 (P< 0 05)； Pgp表达与肿瘤浸润深度 (P< 0 01)、淋巴结转移 (P< 0 05)及 PTNM分期 (P< 0 05)有关；胃癌组织中 Pgp高水平表达者术后生存率较 Pgp低水平表达者为低 (P< 0 01).结论在胃癌化疗前后检测 Pgp将有助于临床上制订合理的化疗方案 ,胃癌组织中 Pgp表达水平是预测胃癌预后的一个有用指标 , Pgp高水平表达者预后较差 .
Objective To investigate the expression of P-glycoprotein (Pgp) in gastric cancer and its relationship with clinicopathological characteristics, preoperative chemotherapy and prognosis of gastric cancer.Methods Immunohistochemistry was used to detect 101 cases of gastric cancer and 20 cases of normal gastric Mucosa and 18 cases of dysplasia tissue.Results The expression of Pgp in gastric cancer with normal gastric mucosa, dysplasia and without preoperative chemotherapy increased in turn (P <0.05), and the expression of Pgp in gastric cancer increased after preoperative chemotherapy (P <005). The expression of Pgp was correlated with the depth of tumor invasion (P <0.01), lymph node metastasis (P <005) and PTNM stage (P <005) The postoperative survival rate of high expression level of Pgp in tissues was lower than that in low level of Pgp expression (P <0.01) .Conclusion The detection of Pgp before and after gastric cancer chemotherapy will help to develop a reasonable chemotherapy regimen in gastric cancer, The expression level is a useful indicator to predict the prognosis of gastric cancer. The high expression of Pgp has a poor prognosis.