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以油酸(0.1ml/kg体重)静脉注入形成大白鼠急性肺损伤模型。观察到注油酸后1天内肺重增加,镜检可见水肿及白细胞在肺间质浸润。支气管肺泡冲洗液(BALF)中蛋白质含量及弹性蛋白酶(ELS)、α-抗胰蛋白酶(α_1-AT)、β-葡萄糖醛酸酶(β-g)活性均明显增高。之后以上变化逐渐减轻。至注油酸后7天,肺组织学检查几乎完全恢复正常,BALF中各指标也降至正常对照水平。提示油酸引起的急性肺损伤可以在较短时间内完全恢复。讨论了ELS和α_1-AT的平衡在损伤修复中的作用。同时提出了油酸除损伤肺脏外,对其它器官的损伤作用值得注意。
Acute lung injury model was induced by intravenous infusion of oleic acid (0.1ml / kg body weight). One day after injection of oleic acid was observed increased lung weight, microscopic examination showed edema and leukocyte infiltration in the lung interstitial. The content of protein and the activity of elastase (α-antitrypsin (α_1 -AT) and β-glucuronidase (β-g) in bronchoalveolar lavage fluid (BALF) were significantly increased. After the above changes gradually reduced. Seven days after oleic acid injection, lung histology almost completely returned to normal, and all indicators in BALF were also reduced to normal levels. Tip oleic acid-induced acute lung injury can be completely recovered in a relatively short period of time. The role of ELS and α_1-AT balance in wound healing was discussed. At the same time, it is noteworthy that the oleic acid not only damages the lung but also damages the other organs.