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目的探讨保留完整子宫功能的意义及子宫功能缺失对机体有些生化指标的影响。方法对168例年龄35～45岁的妇女及166例同等条件妇女因子宫肌瘤手术治疗和子宫动脉栓塞治疗(UAE)的患者,分别于手术前及手术后6、12、24个月测定外周血促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)、甘油三酯(TG)、胆固醇总量(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(ApOA1)和载脂蛋白B(ApOB),并行OGTT实验(对OGTT两项异常认为糖耐量异常),骨密度测量,同时对性生活满意度,泌尿生殖道感染情况进行对比研究,对检测结果进行统计学处理,采用T检验及卡方检验,计算P值,P<0.05为有显著性差异,P<0.01为有特别显著性差异。结果育龄妇女手术后性激素FSH、LH、T均有升高(P<0.01),E2、P下降(P<0.01);血中TG、LDL、ApOB浓度升高(P<0.05～P<0.01),HDL、ApOA1明显下降(P<0.01);OGTT两项异常者明显增多(P<0.05);骨密度下降(P<0.05)。
Objective To investigate the significance of preserving intact uterine function and the effects of uterine function loss on some biochemical indexes in the body. Methods A total of 168 patients aged 35-45 years and 166 women with the same condition underwent Uterine artery embolization (UAE) for Uterine artery embolization (UAE). The peripheral and peripheral blood samples were collected before and 6, 12 and 24 months after operation FSH, LH, E2, P, T, TG, TC, high-density HDL, LDL, apolipoprotein A1 (ApOA1) and apolipoprotein B (ApOB), parallel OGTT test (impaired glucose tolerance in both OGTT abnormalities), bone mineral density measurement Sexual satisfaction and genitourinary tract infection were compared, the test results were statistically processed using the T test and chi-square test to calculate the P value, P <0.05 for significant differences, P <0.01 for the special Significant difference. Results The levels of sex hormones FSH, LH and T were elevated (P <0.01) and the levels of E2 and P were decreased in women of childbearing age (P <0.01). The levels of TG, LDL and ApOB in blood were increased , HDL and ApOA1 decreased significantly (P <0.01). The two abnormalities of OGTT increased significantly (P <0.05) and the BMD decreased (P <0.05).