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建立了测定兔血清中依诺沙里的高效液相色谱仪检测法，方法平均回收率为92.9％，最低检出浓度为1.7μg。研究了急性实验性肝肾损伤家兔（各5只）口服1次依诺沙星后的药代动力学。其血药浓度-时间数据用二室模型拟会，肝损伤组消除相指数、消除相半衰期、消除速率常数及清除率4个药代动力学参数与对照组相比差异无显著意义;肾损伤组4个参数与对照组相比有显著差异。结果显示肾损伤组对依诺沙星的清除率明显减慢，故肾损伤时有必要减少用药剂量及给药次数。
A HPLC method for the determination of enoxaparin in rabbit serum was established. The average recovery rate was 92.9% and the minimum detectable concentration was 1.7μg. The pharmacokinetics of enoxacin after oral administration of acute experimental liver and kidney injury in rabbits (5 rats each) were studied. The plasma concentration-time data were simulated by two-compartment model. There was no significant difference in the four pharmacokinetic parameters between the liver injury group and the control group in terms of elimination phase index, elimination phase half-life, elimination rate constant and clearance rate; renal injury Group 4 parameters compared with the control group were significantly different. The results showed that renal injury group of enrofloxacin clearance was significantly slowed down, it is necessary to reduce the dose of renal injury and administration times.