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作者用多克隆兔抗人纤溶酶原抗体和过氧化物酶标记单克隆抗α2-纤溶酶抑制质(α2PI)抗体,以酶联免疫吸附试验法(一步夹心ELISA)测定48例DIC患者血浆纤溶酶-α2-纤溶酶抑制质复合物(α2PIC),并测定了α2PI等血凝和纤溶指标。DIC的潜在疾患包括各种类型急性白血病(24例)、恶性实体瘤(7例)、败血症(6例)、血管性疾患(8例)和其他疾病(3例)。结果在DIC发病时48例血浆α2PIC增至7.9±4.26mg/L,范围1.1-20.8mg/L(正常值低于0.8mg/L)。缓解时(28例)降至1.9±1.49mg/L,范围0.3-5.9mg/L,其中16例(57.1%)仍>1.0mg/L。在各DIC亚组中急性早幼粒细胞白血病患者(10例)
The authors used polyclonal rabbit anti-human plasminogen antibody and peroxidase labeled monoclonal anti-α2-plasminogen inhibitor (α2PI) antibody, enzyme-linked immunosorbent assay (one-step sandwich ELISA) 48 cases of DIC patients Plasma plasmin - α2-plasmin inhibitor complex (α2PIC), and measured α2PI and other indicators of hemagglutination and fibrinolysis. Potential conditions of DIC include various types of acute leukemia (24 cases), malignant solid tumors (7 cases), sepsis (6 cases), vascular disorders (8 cases) and other diseases (3 cases). Results In the onset of DIC 48 plasma α2PIC increased to 7.9 ± 4.26mg / L, the range of 1.1-20.8mg / L (normal value of less than 0.8mg / L). In remission (28 cases), it dropped to 1.9 ± 1.49 mg / L in the range of 0.3-5.9 mg / L, with 16 cases (57.1%) still> 1.0 mg / L. In each DIC subgroup of patients with acute promyelocytic leukemia (n = 10)