膀胱癌病因研究中,在化学致癌方面,以职业性芳香胺类致癌的研究最多,历史亦最长,并获得肯定的结论。与此有联系的是内源性色氨酸代谢异常,导致尿中芳香胺类代谢产物增加及其与膀胱癌关系的研究,五十年代后期开始有人注意到吸烟可使肺癌与膀胱癌的发病同时升高,对这个问题的探 In the study of the etiology of bladder cancer, in terms of chemical carcinogenesis, occupational aromatic amine carcinogenesis has been the most studied and the history is the longest, and a positive conclusion has been obtained. Related to this is the endogenous metabolism of tryptophan, leading to an increase in urine aromatic amine metabolites and its relationship with bladder cancer. In the late fifties, it was noted that smoking may contribute to the development of lung cancer and bladder cancer. At the same time rising, exploration of this issue