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目的比较胰岛素泵(CSⅡ)和皮下多次注射胰岛素法(MSⅡ)治疗2型糖尿病(T2DM)的疗效和安全性。方法回顾性分析郑州大学第一附属医院2009年6月—2011年1月住院治疗的68例诊断为2型糖尿病(T2DM)患者的临床资料,随机分为两组,分别给予胰岛素泵(CSⅡ)和皮下多次注射胰岛素法(MSⅡ)治疗,依据血糖水平调整胰岛素用量至血糖达标,观察两组患者血糖达标所用的时间、胰岛素用量及低血糖发生率。结果 CSⅡ组和MSⅡ组患者血糖达标时间为(5.50±1.54)d、(7.56±1.54)d,P<0.01;胰岛素用量(33.38±5.00)U、(36.88±4.75)U,P<0.01;低血糖发生率(0.03±0.01)%、(0.13±0.02),P<0.01。两组患者的血糖达标时间、胰岛素用量及低血糖发生率均有显著性统计学差异。结论 CSⅡ组患者血糖达标时间短,胰岛素用量少,低血糖发生率低。CSⅡ可以更快地控制血糖,安全性更高。
Objective To compare the efficacy and safety of insulin pump (CS Ⅱ) and subcutaneous injection of insulin (MS Ⅱ) in the treatment of type 2 diabetes mellitus (T2DM). Methods The clinical data of 68 patients diagnosed with type 2 diabetes mellitus (T2DM) admitted to the First Affiliated Hospital of Zhengzhou University from June 2009 to January 2011 were retrospectively analyzed. The patients were randomly divided into two groups and received insulin pump (CS Ⅱ) And subcutaneous injection of insulin (MS Ⅱ) treatment, according to the level of blood glucose to adjust the amount of insulin to reach the standard of blood glucose, blood glucose in patients with two groups to observe the time, insulin dosage and incidence of hypoglycemia. Results The blood glucose level of CSⅡ group and MS Ⅱ group was (5.50 ± 1.54) d, (7.56 ± 1.54) days, P <0.01; the dosage of insulin was 33.38 ± 5.00 U, (36.88 ± 4.75) U, P <0.01; The incidence of blood glucose was (0.03 ± 0.01)%, (0.13 ± 0.02), P <0.01. Two groups of patients with blood glucose compliance time, insulin dosage and incidence of hypoglycemia were statistically significant differences. Conclusion The patients in CS Ⅱ group had short blood glucose, less insulin dosage and low incidence of hypoglycemia. CS Ⅱ can control blood sugar faster, more secure.