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药物动力学是现代药物研究的重要内容之一,而避孕药作为育龄女性常用药物也需要关注其体内血药浓度范围。因避孕药体内含量低,内源性干扰大,需选用适宜的检测方法才能进行测定。本文以国内、外近年来的研究结果为依据,分别介绍了高效液相色谱法、气质联用法、免疫分析法、同位素示踪法等分析方法在避孕药药物动力学研究中的应用,并概括了各种方法的优缺点和应用范围,为后续避孕药药物动力学的研究提供参考。
Pharmacokinetics is an important part of modern drug research, and contraceptives as a commonly used drug for women of childbearing age also need to pay attention to their range of plasma concentrations. Due to the low content of contraceptives in vivo, endogenous interference, the need to select the appropriate detection methods to be measured. Based on the research results at home and abroad in recent years, this paper introduces the application of HPLC, GC / MS, immunoassay, isotope tracer method in pharmacokinetics of contraceptives, and summarizes The advantages and disadvantages of various methods and the scope of application for the subsequent study of pharmacokinetics of contraceptives provide a reference.