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为探讨微量元素在原发性肝癌亚细胞组分中的分布及在肝癌发生发展中的变化,采用分子活化分析方法测定了肝癌和正常肝脏细胞亚细胞组分中的17种不同宏量和微量元素的分布,t检验比较两者之间的元素含量的差别。结果发现Br、Ca、Cd和Cs在肝癌各亚细胞组分中的含量明显高于正常人,大部分具有统计学显著性差异。肝癌微粒体Fe明显低于正常人肝,为正常人的一半(P<0.05),而其它亚细胞组分均高于正常人肝。La和Ce的分布与Fe类似。Sb和Zn在肝癌细胞核中的含量则明显低于正常人肝(P<0.05、P<0.05)。K、Na在肝癌胞浆的含量明显高于正常人(P<0.05)。Ba和Rb在肝癌和正常肝脏的分布没有显著性差异。本文还探讨了Fe、Cd和K等元素含量的变化与肝癌发生的关系。肝癌与正常肝脏的亚细胞组分之间,多数微量元素的空间分布有着显著不同,提示微量元素在肝癌发生发展中起着重要作用。
In order to explore the distribution of trace elements in primary hepatocellular subcellular components and their changes in the occurrence and development of hepatocellular carcinoma, 17 kinds of macroscopic and trace amounts of subcellular components in hepatocellular carcinoma and normal liver cells were determined by molecular activation assay The distribution of elements, t test to compare the difference between the two elements. The results showed that the content of Br, Ca, Cd and Cs in all subcellular components of hepatocellular carcinoma was significantly higher than that of normal people, most of which had statistically significant difference. Liver cancer microsomal Fe was significantly lower than normal human liver, half of normal (P <0.05), while other subcellular components were higher than normal human liver. The distribution of La and Ce is similar to that of Fe. The contents of Sb and Zn in liver cancer cells were significantly lower than those in normal human liver (P <0.05, P <0.05). K, Na in the cytoplasm of liver cancer was significantly higher than normal (P <0.05). There was no significant difference in the distribution of Ba and Rb between HCC and normal liver. This article also explored the Fe, Cd and K elements such as changes in the relationship with the occurrence of liver cancer. The distribution of most trace elements in the subcellular components of hepatocellular carcinoma and normal liver is significantly different, suggesting that trace elements play an important role in the development of hepatocellular carcinoma.