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目的比较黄体酮、烯丙雌醇两种黄体支持方法对促排卵与宫腔内人工授精妇女体内激素水平及其结果的影响,探讨烯丙雌醇应用于辅助生殖领域中的临床意义。方法2003-06-2004-09北京协和医院前瞻性分析54个促排卵与宫腔内人工授精周期的结果,患者经超声监测确定排卵日期,将排卵后的患者随机分为两组:烯丙雌醇组27例自排卵当日起服用烯丙雌醇进行黄体支持;黄体酮组27例,应用黄体酮进行黄体支持。所有患者于排卵后第0、3、6、9、12、15天取血进行人绒毛膜促性腺激素(HCG)、催乳激素(PRL)、雌二醇(E2)和孕酮(P)测定。结果两组妊娠率、流产率比较差异无统计学意义(P>0.05)。两组排卵后第0、3、6、9、12、15天血清HCG、PRL、E2差异无统计学意义,孕酮水平在排卵后第9天和第12天差异有统计学意义(P<0.05、P<0.01)。两组中的妊娠患者各检测点孕酮水平经比较差异无统计学意义(P>0.05)。两组继续妊娠患者,至妊娠3个月末,每周检测HCG、PRL、E2、P水平经比较差异均无统计学意义(P>0.05)。结论烯丙雌醇在辅助生育技术中进行黄体支持的临床疗效与黄体酮相似,作为口服制剂是辅助生育技术中进行黄体支持的一种较好选择。
Objective To compare the effects of progesterone and allylestrenol support on hormone levels and their effects in ovulation induction and intrauterine insemination women and to explore the clinical significance of allyl estradiol in the field of assisted reproduction. Methods 2003-06-2004-09 Peking Union Medical College Hospital prospectively analyzed 54 ovulation induction and intrauterine insemination period results, the patient was monitored by ultrasound to determine the date of ovulation, the ovulation patients were randomly divided into two groups: alveolar In the group of alcohol, 27 cases received luteal support with allystradiol on the day of ovulation, 27 cases received progesterone, and progesterone was used for luteal support. All patients took blood on day 0, 3, 6, 9, 12 and 15 after ovulation for determination of human chorionic gonadotropin (HCG), prolactin (PRL), estradiol (E2) and progesterone . Results There was no significant difference in pregnancy rate and abortion rate between the two groups (P> 0.05). Serum HCG, PRL and E2 had no significant difference on the 0, 3, 6, 9, 12 and 15 days after ovulation in both groups, and there was significant difference between the 9th and 12th day after ovulation (P < 0.05, P <0.01). There was no significant difference in progesterone levels between pregnant women and pregnant women in both groups (P> 0.05). There was no significant difference in the levels of HCG, PRL, E2 and P between the two groups of patients who continued to be pregnant until the end of the third trimester of pregnancy (P> 0.05). Conclusions The clinical efficacy of allyl estradiol for prolactin support in assisted reproductive technology is similar to that of progesterone. As an oral preparation, it is a better choice for luteal support in assisted reproductive technology.