目的:探讨盐酸戊乙奎醚(长托宁)对创伤性急性肺损伤(ALI)炎症反应影响及可能的机制。方法:建立创伤性急性肺损伤大鼠模型。实验动物随机分为正常对照(C)组、创伤模型(M)组、长托宁干预(P)组,每组24只。各组动物进行动脉血气、肺湿/干质量(W/D)比值、肺组织髓过氧化物酶活性(MPO)、血清中肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平、光镜和电镜下观察肺组织损伤情况比较。结果:长托宁治疗后能不同程度降低TNF-α和IL-6的含量(P<0.01,P<0.05),明显改善创伤性急性肺损伤动物的血气(P<0.05),减少肺W/D(P<0.05)和MPO值(P<0.05),减轻肺组织的损伤程度。结论:促炎性细胞因子在创伤性ALI的发生、发展过程中起着重要作用;长托宁发挥抗炎作用与其对炎性细胞因子的调节作用密切相关。 Objective: To investigate the effect and possible mechanism of penehyclidine hydrochloride (SCT) on the inflammatory response of traumatic acute lung injury (ALI). Methods: To establish a rat model of traumatic acute lung injury. The experimental animals were randomly divided into normal control group (C), trauma model group (M) and penehyclidine intervention group (P), 24 rats in each group. The arterial blood gas, W / D ratio, pulmonary myeloperoxidase (MPO), serum tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL- 6) levels, light microscopy and electron microscopy lung injury comparison. Results: After treated with penehyclidine for a long time, the levels of TNF-α and IL-6 could be decreased to some extent (P <0.01, P <0.05), and the blood gas of traumatic acute lung injury (P0.05) D (P <0.05) and MPO (P <0.05), and alleviated the degree of lung injury. CONCLUSION: Pro-inflammatory cytokines play an important role in the pathogenesis and development of traumatic ALI. Penehyclidine exerts anti-inflammatory effects and is closely related to its regulation of inflammatory cytokines.