论文部分内容阅读
目的应用体外干扰实验评价丹红注射液、注射用血栓通2种活血化瘀类的中药注射剂对临床凝血功能项目检测的干扰。方法收集本院未服用任何药物的健康体检者血浆样本,根据CLSI EP7-2A推荐的干扰试验方法进行体外干扰研究,分别测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)和凝血酶时间(TT),通过配对差异实验确定所选药物对凝血项目是否存在干扰。结果丹红注射液对PT、FIB 2个项目存在干扰;血栓通注射液对PT、APTT、FIB、TT均存在干扰。结论 2种活血化瘀类的中药注射剂对凝血功能检验项目存在不同程度的干扰。
Objective To evaluate the interference of Danhong injection and Xueshuantong injection of traditional Chinese medicine for promoting blood circulation to remove blood stasis in clinical coagulation function test by in vitro interference experiment. Methods Plasma samples of healthy subjects who did not take any drugs in our hospital were collected and in vitro interference studies were conducted according to the interference test method recommended by CLSI EP7-2A. Prothrombin time (PT), activated partial thromboplastin time (APTT) Plasma Fibrinogen (FIB) and Thrombin Time (TT) were used to determine if the drug of choice was interfering with the coagulation program by paired difference experiments. Results Danhong injection had interference on PT and FIB 2 items. Xueshuantong injection could interfere PT, APTT, FIB and TT. Conclusion There are two kinds of traditional Chinese medicine injection for promoting blood circulation and removing blood stasis, which have different degrees of interference on coagulation test items.