论文部分内容阅读
目的探讨经治重型β地中海贫血(以下简称地贫)股骨骨髓的 MRI 特征。方法对35例重型β地贫行股骨近段 MR 检查,同时选取年龄、性别匹配的正常儿童45例作为对照。对股骨骨髓进行 SE、快速场回波序列(fast field echo,FFE)冠状面成像。在 SE T_1WI 上判断红黄骨髓并将骨髓分布分为5组,在 FFE 序列上判断骨髓内的铁沉积,并进行临床相关性分析。结果 35例地贫,FFE 序列上15例股骨近端骨髓出现铁沉积,红黄骨髓表现为极低信号。骨髓的铁沉积与年龄有关(P=0.032)。T_1WI 上,30例重型地贫骨髓分布为Ⅲ和Ⅳ组,而正常儿童为Ⅰ和Ⅱ组,两者之间差异有统计学意义(P<0.001),且重型地贫骨髓分组与输血量相关(P=0.049)。结论经治重型地贫股骨近段骨髓红骨髓增生,骨髓内可出现铁沉积。骨髓的增生与输血治疗、铁沉积及年龄有一定的关系。
Objective To investigate the MRI features of femur bone marrow in patients with severe β-thalassemia major (referred to as thalassemia). Methods 35 cases of severe β-thalassemia performed proximal femur MR examination, while 45 cases of normal children and age-matched gender were selected as controls. The femur bone marrow was subjected to SE and coronal plane imaging of fast field echo (FFE). Red-yellow bone marrow was determined on SE T-1WI and the bone marrow distribution was divided into 5 groups. The iron deposition in the bone marrow was judged on the FFE sequence, and clinical correlation analysis was performed. Results Totally 35 cases of thalassemia, FFE sequence of 15 cases of proximal femur bone iron deposition, red and yellow bone marrow showed a very low signal. Iron deposition in the bone marrow was age-related (P = 0.032). T_1WI, the distribution of bone marrow in 30 patients with severe thalassemia was in group Ⅲ and Ⅳ, while in normal children was in group Ⅰ and Ⅱ, the difference was statistically significant (P <0.001) (P = 0.049). Conclusions The myeloid hyperplasia in the bone marrow of the proximal femur of critically ill teenagers can cause iron deposition in the bone marrow. Bone marrow hyperplasia and blood transfusion, iron deposition and age have a certain relationship.