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双氢埃托啡(dihydroetorphine简称DHE)经动物试验证明有强效镇痛作用,长期给药成瘾性较小,临床应用镇痛效果好,副作用少,但有效时间较短。为克服频繁注射给药的烦琐,黄矛等研究了DHE舌下给药的药效学,并测定了其血、脑中浓度。证明DHE能通过舌下吸收。这就为DHE在慢性疼痛患者的应用提供了方便的剂型。本文报道1982年在307医院肿瘤科应用DHE的注射剂和舌下含片对24例晚期肿瘤患者的镇痛效果。
Dihydroetorphine (DHE) has been proved to have potent analgesic effects in animal experiments. It has little long-term drug addiction, good analgesic effect in clinical application, few side effects, but short effective time. In order to overcome the cumbersomeness of frequent injections, Huang Mao et al. Studied the pharmacodynamics of DHE sublingual administration and determined the blood and brain concentrations. DHE proved to be absorbed through the tongue. This provides a convenient dosage form for the use of DHE in patients with chronic pain. This article reports the analgesic effect of intradermal injection of DHE and sublingual tablet in the oncology department of 307 hospital in 1982 on 24 patients with advanced cancer.