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目的研究5%和10%氯代水杨胺缓释颗粒剂(LDS-SRG)的制备方法及其杀螺效果。方法筛选载体、表面活性剂、黏合剂、消泡剂、润滑剂,制备5%和10%的LDS-SRG。对其堆密度、水分含量、休止角、临界相对湿度、热贮稳定性和释放速度进行测定。在实验室条件下以剂量1.6 g/m~2(喷撒法)测试LDS-SRG的杀螺效果,设置50%氯硝柳胺乙醇胺盐可湿性粉剂(WPN)1.0 g/m~2药物对照组和空白对照组(脱氯水),分别计算施药后3、7、14 d钉螺的死亡率。结果制备的5%和10%的LDS-SRG均为红褐色,流动性良好;其堆密度分别为0.655 g/ml和0.594 g/ml;水分含量分别为1.15%和1.28%;休止角分别为39.8°和39.7°;临界相对湿度分别为64.98%和61.63%;热贮稳定性均良好。释放曲线表明,5%、10%的LDS-SRG第1~9天均平稳释放,5%LDS-SRG释放速度大于10%LDS-SRG;药物快速释放分别出现在第10天和第15天;并分别在第14天和第20天逐步趋于平稳。实验室喷撒结果显示,5%LDS-SRG 1.6 g/m2施药后7 d、10%LDS-SRG 1.6 g/m2施药后14 d,钉螺的死亡率均>95%,且均高于50%WPN 1.0 g/m~2对照组,差异有统计学意义(P<0.05)。结论 5%和10%的LDSSRG经实验室测试达到缓释效果,采用喷撒法灭螺,均达到农药登记用杀钉螺剂药效评价指标要求。
Objective To study the preparation and killing effect of 5% and 10% L-salicylamide sustained-release granules (LDS-SRG). Methods Screening carriers, surfactants, binders, defoamers, lubricants, 5% and 10% LDS-SRG were prepared. The bulk density, moisture content, angle of repose, critical relative humidity, heat storage stability and release rate were determined. The killing effect of LDS-SRG was tested at a dose of 1.6 g / m ~ 2 (spraying method) under laboratory conditions. A 50% niclosamide ethanolamine salt wettable powder (WPN) 1.0 g / m ~ Group and blank control group (dechlorinated water). The mortality of snails on 3, 7 and 14 d after treatment were calculated respectively. Results The 5% and 10% LDS-SRG were red-brown and had good fluidity. The bulk density was 0.655 g / ml and 0.594 g / ml, respectively. The moisture contents were 1.15% and 1.28% 39.8 ° and 39.7 ° respectively; the critical relative humidity was 64.98% and 61.63% respectively; and the heat storage stability was good. The release curves showed that 5% and 10% of LDS-SRG released smoothly on the 1st to 9th day and the release rate of 5% LDS-SRG was greater than 10% LDS-SRG. The fast release of drug occurred on the 10th and 15th days, respectively. And gradually stabilized on the 14th and 20th days respectively. Laboratory spraying results showed that on the 14th day after application of 5% LDS-SRG 1.6 g / m2 and 10% LDS-SRG 1.6 g / m2, the mortality of snails was> 95% 50% WPN 1.0 g / m ~ 2 control group, the difference was statistically significant (P <0.05). Conclusions 5% and 10% LDSSRG reached the sustained-release effect through laboratory tests. The snail sprinkling method was used to kill the snails.