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目的探讨达英-35联用二甲双胍治疗多囊卵巢综合征(PCOS)的疗效。方法选择2007年9月-2010年12月在我院诊治的多囊卵巢综合征患者70例,其中35例曾用达英-35治疗,另外35例曾用达英-35联合二甲双胍治疗,连续治疗3个月。比较治疗前后临床症状、内分泌和生化指标的改变。结果两组治疗后月经恢复,血促黄体生成素、睾酮明显下降(P<0.01),空腹血糖无变化。单用达英-35组体重指数和空腹胰岛素无变化,联合用药组体重指数明显降低,空腹胰岛素下降(P<0.05),排卵率、妊娠率都较单用达英35组高。结论采用二甲双胍联合达英-35对PCOS进行治疗,能有效降低雄激素水平,改善胰岛素抵抗,疗效优于单用达英-35。
Objective To investigate the curative effect of da-Ying-35 combined with metformin on polycystic ovary syndrome (PCOS). Methods Seventy patients with polycystic ovary syndrome who were diagnosed and treated in our hospital from September 2007 to December 2010 were selected. Among them, 35 cases were treated with Ying-35 and the other 35 cases were treated with Da-Ying-35 combined with metformin for continuous Treatment for 3 months. Before and after treatment, clinical symptoms, endocrine and biochemical changes. Results After the treatment, the menstruation recovered, the serum luteinizing hormone and testosterone were obviously decreased (P <0.01), and the fasting blood glucose did not change. Body weight index and fasting insulin alone were not changed in combination with daphnine-35 group. The body weight index of the combination group was significantly lower and the fasting insulin was decreased (P <0.05). The ovulation rate and pregnancy rate were all higher than those of the control group. Conclusions The treatment of PCOS with metformin and da-Ying-35 can effectively reduce androgen levels and improve insulin resistance, and the curative effect is better than that of daphnine-35 alone.