论文部分内容阅读
肾脏是绝大多数药物的排出器官,其功能如何必然影响药物作用的久暂及强弱。因此,怎样为肾功能衰竭(简称肾衰)病人选择及合理使用药物,是急待解决的问题之一。为此,现按临床用药情况,结合药代动力学知识,对肾衰者的用药作一综述。一、利尿药 (一)不必减量的 1.速尿本药大部分由肾小球滤过及近曲小管分泌呈原形排出。因排泄快,蓄积作用多不严重。利尿作用与剂量有关,而且个体差异较大,如有的病人25 mg/日就有效,而有的需100～150 mg/次,2次/日才有效。
Kidney is the most organ of the excretion of organs, how its function will inevitably affect the long-term effects of drugs and strength. Therefore, how to choose and reasonably use drugs for patients with renal failure (referred to as renal failure) is one of the urgent problems to be solved. To this end, now according to clinical medication, combined with pharmacokinetic knowledge, the treatment of renal failure were reviewed. First, diuretics (a) do not have to reduce the 1. Speed urine most of the drug by the glomerular filtration and proximal convoluted tubule secretion was the prototype discharge. Due to excretion fast, accumulation is not serious. Diuretic effects and dose-related, and individual differences, such as some patients 25 mg / day is effective, while others need 100 ~ 150 mg / time, 2 times / day to be effective.