硝酸镓是一种重金属类抗癌剂,经临床Ⅰ期研究证实,对成骨肉瘤,平滑肌肉瘤,甲状腺癌,肺小细胞癌,黑色素瘤,神经嵴瘤,卵巢癌,何杰金氏病和非何杰金氏病性淋巴瘤,以及膀胱癌等都有抗肿瘤作用,主要优点是没有骨髓抑制毒副作用。本研究选用经组织学证明的二组34例已有转移病变有晚期膀胱癌患者,进行硝酸镓的临床应用观察,以700mg/M~2溶于200ml生理盐水中静脉输注,二周后重复给药一次,第一组10例出现较严重的肾毒副作用,血清肌酐超过4.0mg/dl,肌酐清除率比用药前减少了50 Barium nitrate is a heavy metal anticancer agent, confirmed by clinical phase I studies, for osteosarcoma, leiomyosarcoma, thyroid cancer, small cell lung cancer, melanoma, neuroblastoma, ovarian cancer, Hodgkin’s disease, and Non-Hodgkin’s lymphoma, as well as bladder cancer, have anti-tumor effects. The main advantage is that there is no myelosuppressive toxic side effects. In this study, 34 patients with metastatic lesions with advanced bladder cancer who were diagnosed by histology were selected and clinically observed for lanthanum nitrate. 700 mg/M~2 was intravenously infused into 200 ml normal saline and repeated two weeks later. After one dose, the first group of 10 patients experienced more severe nephrotoxicity, serum creatinine was over 4.0 mg/dl, and creatinine clearance was reduced by 50