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应用膜片钳技术,全细胞钳位方式可见Mex对大鼠背根神经节细胞Na~+电流有明显的抑制作用。其临界作用浓度为5 μmol·L~(-1),50％抑制浓度为31 μmol·L~(-1),完全抑制浓度为150 μmol·L~(-1)。其抑制作用具有电压和频率依赖性。抑制剂量与小鼠抗脑缺血缺氧作用量相近。提示Mex抗脑缺血缺氧作用的机制之一可能是通过对Na~+电流的抑制。
Patch clamp technique was used to observe the effect of Mex on Na ~ + currents in rat DRG neurons. The critical concentration was 5 μmol·L -1, the 50% inhibitory concentration was 31 μmol·L -1, and the complete inhibitory concentration was 150 μmol·L -1. Its inhibitory effect is voltage and frequency dependent. Inhibition dose and anti-cerebral ischemia and hypoxia similar amount of mice. Tip Mex anti-cerebral ischemia and hypoxia one of the mechanisms may be through the inhibition of Na ~ + current.