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目的探讨合并侵袭性真菌感染白血病的临床病理特征以提高对本病的认识。方法回顾性分析我院1956—1988年剖检的16例合并侵袭性真菌感染的白血病患者临床及病理资料。结果 (1)以发热、咳嗽、咳痰及咯血等为主要症状。(2)肺部X线检查病变者主要表现为斑点状、絮状、片状影。(3)外周血白细胞计数:>4×109/L 6例,<4×109/L 10例,中性粒细胞<0.5×109/L 5例。(4)侵袭性真菌感染发生率为22.2%;7例为毛霉菌感染,9例为曲霉菌感染;肺部感染11例,真菌性败血病5例。结论侵袭性真菌感染的临床表现常无明显特征性,病情进展迅速,病死率高,临床应引起重视。
Objective To investigate the clinical and pathological features of leukemia complicated with invasive fungal infection in order to improve the understanding of this disease. Methods The clinical and pathological data of 16 leukemia patients with invasive fungal infection in our hospital from 1956 to 1988 were analyzed retrospectively. Results (1) with fever, cough, sputum and hemoptysis as the main symptoms. (2) Pulmonary X-ray examination of the main manifestations of spot-like, floc, sheet shadow. (3) Peripheral blood leukocyte count:> 4 × 109 / L 6 cases, <4 × 109 / L 10 cases, neutrophils <0.5 × 109 / L 5 cases. (4) The incidence of invasive fungal infection was 22.2%; 7 cases were Mucor infection, 9 cases were Aspergillus infection; 11 cases were pulmonary infection and 5 cases were fungal septicemia. Conclusion The clinical manifestations of invasive fungal infection often have no obvious characteristic, rapid progression, high mortality, clinical should pay attention.