To analyze the mechanism of drag reducing effect by coupling flexible tubes with turbulent flow, based on experimental examination of more obvious turbulent drag reduction effect in flexible tubes than in rigid tubes, experimental investigation was performed on the effect of turbulent drag reduction, fluctuating vibration characteristics of flexible tube and the correlations by using a double-tube system and laser displacement sensor. The results are as follows: with the decrease of the thickness of the flexible tubes, the root mean square of fluctuating amplitude of the outer wall of the tubes increases, and the non-dimensional burst period increases, resulting in the increase of the reduction rate of drag coefficient by coupling flexible tubes with turbulent flow. At applied pressure-balanced air on the outer wall and the Reynolds number of about 1.75 104, the non-dimensional burst periods of the flexible tubes with the thickness of 2 mm, 3 mm, 4 mm are 141, 126, 105, respectively.