为了将生长缓慢的骨髓瘤细胞暴露在细胞毒化疗中的时问更长,Barlogie于1984年介绍了长春新硷(VCR)和阿霉素(ADM)输注治疗多发性骨髓瘤(MM)的方法。作者最初应用VAMP方案,即VCR和ADM输注加甲基强的松龙(MP)治疗一组复发或难治性MM患者,证实有显著的临床疗效。这一结果提示,应用此方案对未经治疗的MM患者作诱导治疗和作为骨 In order to extend the exposure of slow-growing myeloma cells to cytotoxic chemotherapy, Barlogie introduced vinorelbine (VCR) and adriamycin (ADM) infusions for multiple myeloma (MM) in 1984. method. The authors initially applied the VAMP regimen, which is an infusion of VCR and ADM plus methylprednisolone (MP) to treat a group of patients with relapsed or refractory MM, demonstrating significant clinical efficacy. This result suggests that the use of this protocol for induction therapy and as bone in untreated MM patients