Angew.Chem.Int.Ed.2012,51,540～543将三氟甲基官能团引入药物分子和农药分子等生物活性分子可以带来很多意想不到的生物活性和代谢特性.目前,对于芳烃的直接碳氢活化三氟甲基化方法仅有为数不多的报道,并且对非官能团诱导底物的高选择性碳氢活化三氟甲基化是一个具有挑战性的课题.中国科学院上海有机化学研究所有机氟化学重点实验室沈其龙小组采用通过 Angew.Chem.Int.Ed.2012,51,540-543 The introduction of trifluoromethyl groups into biologically active molecules such as drug molecules and pesticide molecules can lead to many unexpected biological activities and metabolic properties.At present, Activated Trifluoromethylation has only a few reports, and non-functional groups to induce high selective substrate Hydrocarbons activated trifluoromethylation is a challenging topic.Shanghai Institute of Organic Chemistry Chinese Academy of Organic Chemistry Key Laboratory of Fluorine Chemistry Shen Qilong team adopted