纤维蛋白连结素(fibronectin,Fn)是存在于血浆和细胞膜表面的一种高分子糖蛋白。它参与细胞——细胞和细胞——间质的连接,与细胞形态的保持、细胞移动、分化、网状内皮系统(RES)的功能、组织修复等有密切关系,且与许多疾病有关。近年来这方面的研究已获得了显著进展。Fn主要有分布于血浆和细胞膜表面的血浆型Fn和细胞型Fn。早在40年代Morrison首先发现血浆中存在一种在低温下不溶的蛋白质,并称为不溶性冷球蛋白(cold insoluble globulin,CIg)。70年代Mosess- Fibronectin (Fn) is a kind of high molecular glycoprotein that exists on the surface of plasma and cell membrane. It is involved in cell-cell and cell-interstitial connections and is closely related to the maintenance of cell morphology, cell migration, differentiation, function of reticuloendothelial system (RES), tissue repair, etc., and is associated with many diseases. In recent years, research in this field has made remarkable progress. Fn is mainly distributed in the plasma and cell membrane plasma-type Fn and cell-type Fn. As early as the 40’s Morrison first discovered in the plasma there is a protein that is insoluble at low temperature and is called cold cold globulin (CIK). 70s Mosess-