溶栓疗法逐渐应用于急性脑梗塞治疗，但易合并颅内出血，死亡率达18～50％［1］。因此脑保护后溶栓及改善微循环的综合治疗，是减少脑出血的有效办法之一，这种方法国内外文献报道甚少。我们最近应用甘露醇、巴白酶及占替诺等综合治疗急性脑梗塞100例，现将临床观察结果报告如 Thrombolytic therapy gradually used in the treatment of acute cerebral infarction, but easy to merge intracranial hemorrhage, the mortality rate of 18 to 50% [1]. Therefore, cerebral protection after thrombolysis and improve microcirculation comprehensive treatment is one of the effective ways to reduce cerebral hemorrhage, this method has little domestic and foreign literature reports. We recently applied mannitol, baipu enzyme and Zhan Pheno and other comprehensive treatment of acute cerebral infarction in 100 cases, the clinical observation results are reported