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目的研究影响T2期直肠癌淋巴结转移的因素,为T2期直肠癌局部切除选择病例提供参考依据。方法回顾分析根治性切除的T2期直肠癌淋巴结转移情况,对患者年龄、性别、病程、肿瘤最大直径、肿瘤离肛缘距离、肿瘤直肠位置、肿瘤占肠腔周径、大体类型、组织分型、分化程度、送检淋巴结数量、浸润深度、术前血CEA、术前血CA199、组织ER、组织PR、组织CEA、组织P53等临床病理参数与淋巴结转移情况进行统计分析。结果 T2期直肠癌淋巴结转移率为23.9%(95/398),淋巴结转移与年龄和术前血CEA相关,与组织类型、浸润深度、分化程度、大体类型有关。logistic多因素回归分析结果显示淋巴结转移情况与肿瘤大体及年龄相关。结论高龄增殖型T2期直肠癌淋巴结转移率相对较低,局部切除可行性较大。
Objective To study the factors that affect the lymph node metastasis in T2 rectal cancer and provide references for the selection of local resection in T2 rectal cancer. Methods Retrospective analysis of radical resection of lymph node metastasis of T2 rectal cancer patients, age, gender, duration of disease, the maximum diameter of tumor, the tumor from the anal verge position, tumor rectum, tumor size of intestinal circumference, gross type, histological type , The degree of differentiation, the number of lymph nodes examined, depth of invasion, preoperative blood CEA, preoperative blood CA199, ER, PR, CEA, P53 and other clinical pathological parameters and lymph node metastasis were statistically analyzed. Results The rate of lymph node metastasis in T2 rectal cancer was 23.9% (95/398). The lymph node metastasis was correlated with age and preoperative blood CEA, and was related to the type of tissue, the depth of invasion, the degree of differentiation and the general type. Logistic multivariate regression analysis showed that lymph node metastasis and tumor size and age-related. Conclusion Lymph node metastasis rate in advanced proliferative T2 rectal cancer is relatively low, and local excision is more feasible.