随着抗生素的发现及在医药领域的发展,它在人们的生活领域中所占地位越来越重要.由于耐药菌的出现,使抗生素的用药量增加,有效性逐渐降低.经研究发现β-内酰胺酶裂解β-内酰胺是使β-内酰胺类抗生素失去活性的主要原因.因此发展新的对β-内酰胺酶稳定的药物或能与有效药物合用的β-内酰胺酶抑制剂,才能使β-内酰胺类抗生素走出这一困境. With the discovery of antibiotics and the development in the field of medicine, it occupies more and more importance in the field of people’s life.As the emergence of drug-resistant bacteria increases the dosage of antibiotics, the effectiveness decreases gradually.Studies have found that β - Lactamase cleaves β-lactam is the main reason for loss of activity of β-lactam antibiotics.Therefore, the development of new β-lactamase-stable drugs or with effective drugs combined β-lactamase inhibitor , In order to make β-lactam antibiotics out of this predicament.