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作者用依诺沙星治疗伤寒41例,诺氟沙星作为对照用药治疗伤寒39例.80例全为住院病人,血培养阳性率83.75%(67/80),按随机分组,两组间的基本情况大致相仿,依诺沙星片0.4g,每日2次,诺氟沙星片0.4g,每日3次,疗程均为14d.结果,依诺沙星组有效率97.67%,诺氟沙星组为87.90%,两组间有非常显著差别(P<0.01).治疗1周后两组细茵均转阴,平均退热时间依诺沙星组比诺氟沙星组短.对治疗有效的病例,随访2周均无复发.不良反应两组相仿,表现为便秘和白细胞下降及皮疹各1例.体外药敏试验及最低抑茵浓度测定依诺沙星与诺氟沙星相近.
The authors used enoxacin to treat 41 cases of typhoid fever and norfloxacin as control drug to treat 39 cases of typhoid fever.80 cases were all inpatients, the positive rate of blood culture was 83.75% (67/80), and were randomly divided into two groups The basic situation is roughly the same, enoxacin 0.4g, 2 times a day, norfloxacin 0.4g, 3 times a day, treatment were 14d.Results enoxacin group 97.67% efficiency, Norfloxacin The difference between the two groups was significant (P <0.01) .After 1 week of treatment, the concanavalin in both groups turned negative, and the mean time to fever in enoxacin group was shorter than that in the norofloxacin group Treatment-effective cases, no recurrence of follow-up of 2 weeks.The adverse reactions were similar in both groups, manifested as constipation and leukopenia and rash in 1 case.Determination of drug sensitivity test and minimum inhibitory concentration in vitro enoxacin and norfloxacin .