凝固酶阴性葡萄球菌对新生儿的致病性日益被人们认识。最近,Battisti 等复习了医院内新生儿败血症的原因,发现医院内感染的病例50%以上与表皮葡萄球菌有关,其中许多病例由血管导管、胸腔插管等引起。其他人则报道了与外物无关的表皮葡萄球菌感染,包括全身性(败血症和脑膜炎)和局部性感染(尿路感染、骨髓炎、化脓性关节炎、中耳炎和肺炎)。虽然正常情况下寄生于肠道的细菌大多为革兰氏阴性细菌,肠球菌和厌氧菌,但近年在婴儿室内表皮葡萄球菌感染逐渐突出,已成为一种重要的肠道病 Coagulase-negative staphylococci pathogenesis of the newborn is increasingly recognized. Recently, Battisti et al. Reviewed the causes of neonatal sepsis in the hospital and found that more than 50% of cases of nosocomial infections were associated with Staphylococcus epidermidis, many of which were caused by vascular catheters and thoracic intubation. Others reported Staphylococcus epidermidis infections unrelated to foreign objects, including systemic (sepsis and meningitis) and localized infections (urinary tract infections, osteomyelitis, suppurative arthritis, otitis media and pneumonia). Although most of the bacteria that normally colonize the intestine are Gram-negative bacteria, enterococci and anaerobes, in recent years, staphylococcus epidermidis infection has gradually become prominent in infants and has become an important intestinal disease