目的:研究葛根对老年性聋大鼠的治疗作用。方法:选取月龄22～24个月Wistar大鼠32只,随机分为4组,每组8只。对4组大鼠皮下注射不同剂量的葛根提取液,共4周,观察各组大鼠ABR的改变,比较各组动物血液流变学指标。结果:注射葛根后老年性聋大鼠反应阈明显改善(P<0.05),血液流变学指标较对照组明显好转(P<0.05),且葛根注射剂量为2g/(kg.d)效果最佳(P<0.01),不良反应较轻。结论:葛根能明显改善老年性聋大鼠听力。本研究为阐明老年性聋的发病机制及临床上治疗老年性聋提供了理论依据。 Objective: To study the therapeutic effect of Pueraria on senile spastic rats. METHODS: Thirty-two Wistar rats aged 22-24 months were randomly divided into 4 groups with 8 in each group. Four groups of rats were injected subcutaneously with different doses of Radix Puerariae extract for a total of 4 weeks to observe the changes of ABR in each group and to compare the hemorheological indexes in each group. RESULTS: The response threshold of senile spasticity rats was significantly improved after injection of Pueraria (P<0.05), and the hemorheology indexes were significantly improved compared with the control group (P<0.05), and the geji injection dose was 2g/(kg.d). Good (P<0.01), adverse reactions were lighter. Conclusion: Pueraria can significantly improve hearing in senile delirium rats. This study provides a theoretical basis for elucidating the pathogenesis of senile spasticity and clinically treating senile spasticity.