论文部分内容阅读
目的 观察畅脉舒预防用药对动脉粥样硬化家兔一氧化氮 (NO)、血浆内皮素 (ET)和血脂的影响。方法 采用高胆固醇喂养 ,建立家兔 AS模型 ,随机分为对照组、模型组和畅脉舒用药组 ,每组在实验第 1 4周取血标本测定上述指标。结果 与模型组比较 ,畅脉舒组能提高 NO、高密度脂蛋白 (HDL )含量 (P<0 .0 5 ,P<0 .0 1 ) ,降低 ET、总胆固醇、甘油三酯和低密度脂蛋白含量 (P<0 .0 1 )。结论 畅脉舒具有调节血脂、保护内皮功能和维持 NO/ET平衡的作用
Objective To observe the effect of Changmaisu on drug-induced nitric oxide (NO), plasma endothelin (ET) and blood lipids in rabbits with atherosclerosis. Methods Rabbits were randomly divided into control group, model group and Changmaishu medication group. The blood samples were measured at the 14th week of the experiment to determine the above indexes. Results Compared with the model group, Changmaishu group can increase NO, high density lipoprotein (HDL) content (P<0.05, P<0.01), decrease ET, total cholesterol, triglyceride, and low density. Lipoprotein content (P < 0.01). Conclusion Changmaishu has functions of regulating blood lipid, protecting endothelial function and maintaining NO/ET balance.