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肿瘤血管能够导致肿瘤疯狂生长,也是肿瘤细胞扩散和转移的秘密通道。因此对肿瘤血管的生成的研究就成为了当前研究的热点。本文对VEGF、MMP、EGFR、bFGF等重要的促血管生成因子与肿瘤血管生成、生长关系的临床证明、病理组织学研究、基因学研究以及以此为靶点的药物治疗的研究现状,尤其是中药治疗研究情况作综述。
Tumor blood vessels can lead to the crazy growth of tumors, but also the secret passage of tumor cells proliferation and metastasis. Therefore, the study of the generation of tumor blood vessels has become the current research hot spots. In this paper, the clinical evidence of the relationship between angiogenic factors such as VEGF, MMP, EGFR, bFGF and tumor angiogenesis and growth, histopathological research, genetics research and drug therapy with this target, especially Chinese medicine treatment research situation review.