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目的：：优选β-环糊精包合酮康唑、硝酸咪康唑的工艺。方法：通过正交试验设计,以β-环糊精与酮康唑的质量比例,包合温度,包合时间为考察因素,筛选出最佳包合工艺。结果：β-环糊精包合酮康唑、硝酸咪康唑的最佳工艺为：β-环糊精与酮康唑质量比为8∶1,包合温度50℃,超声包合时间50 min。结论：优选的包合工艺简单易行。“,”Objective:To optimize the preparation technology of ketoconazole and miconazole nitrateβ-cyclodextrin inclusion com-pound. Methods: The weight ratio of β-cyclodextrin to ketoconazole, inclusion temperature and inclusion time as the testing factors, the optimal inclusion technology was screened by orthogonal experiments. Results:The optimum inclusion conditions were as follows:the weight ratio of β-cyclodextrin to ketoconazole was 8 ∶1, the inclusion temperature was 50℃, and the ultrasonic time was 50 min. Conclusion:The optimized β-cyclodextrin inclusion process is simple and convenient to carry out.