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Objective To compare the difference of effect while using homograt pericardium patch and Gore-tex patch in staged complete repair for Tetralogy of Fallot (TOF) to enlarge the right ventricular ouflow tract (RVOT). Methods Twenty-eight patients with TOF underwent the staged complete repair. Gore-tex patches were used to enlarge the RVOT of 13 patients, and cryopreserved homograft pericardium patches were used to enlarge the RVOT of 15 patients. The patients were followed up with 2-dimensional echocardiography and chest x-ray.Results One operative death in Gore-tex patch group, the mortality was 7. 7%; 1 early postoperative death in cryopreserved homograft pericardium patch group, the mortality was 6. 7%. Between 2 groups, hemostasia time in operation room with significant difference ( P ＜ 0. 01 ) , pericardial cavity drainage volume with difference ( P ＜ 0. 05). Gore-tex patch group was followed up 2 to 4.5 years, homograft pericardium patch group was followed up 0. 8 to 2. 1 years. Echocardiography showed that there was significant difference of the residual obstruction at RVOT level ( P ＜ 0. 01 ). No calcification shadow was discovered on the chest x-ray of both groups. Conclusion Homograft pericardium is tissue with high density and intensity, its elasticity and compliance are good. Using homograft pericardium patch maybe helpful to decrease the residual obstruction of RVOT after operation. It can be adapted as a repairing material in cardiac surgery.