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根据肝病临床病症特点,分析目前常用的肝损伤动物模型,探讨现有肝损伤模型与临床病症的吻合情况及应用前景。现有的肝损伤动物模型主要有化学性、药物性、免疫性、酒精性,在一定程度上代表临床肝纤维化、肝硬化、病毒性肝病、酒精性肝病等病症。肝病造模方法较多,但缺少能反映肝病临床病症特点、体现肝病中医病因的动物模型复制,与临床病症仍存在一定差距。笔者根据现有肝损伤模型与临床病症特点的吻合程度及以中医证候特点,提出了制作与临床症状更为接近的病症结合肝损伤动物模型的设想,为中医药治疗肝病的研究提供可靠的实验方法。
According to the characteristics of clinical symptoms of liver disease, we analyzed the common animal model of liver injury and explored the anastomosis and application prospect of the existing liver injury model and clinical symptoms. The existing animal models of liver injury are mainly chemical, pharmaceutical, immune, alcohol, to some extent on behalf of clinical liver fibrosis, cirrhosis, viral liver disease, alcoholic liver disease and other diseases. There are many ways to make liver diseases, but there is still a lack of replication of animal models that reflect the clinical features of liver diseases and the causes of liver diseases. There is still a gap between them and clinical symptoms. According to the existing degree of anastomosis of liver injury model and clinical symptoms and characteristics of traditional Chinese medicine syndrome, the author put forward the idea of making an animal model of liver injury which is more close to the clinical symptoms and provide a reliable basis for the study of traditional Chinese medicine in the treatment of liver disease experimental method.